|
KMID : 0363720070400010001
|
|
Korean Journal of Anatomy
2007 Volume.40 No. 1 p.1 ~ p.10
|
|
|
Effect of Pdx1 Expression after Sox9 Depletion in the Early Pancreatic Development in African Clawed Frog (Xenopus laevis)
|
|
Park Byung-Yong
Li Li-Guang
Choi Eun-Hye
Jung Mong-Yong
Kwon Ki-Tak
Jeong Yeon-Ho
Kim Jong-Youn
Kim In-Shik
Park Byung-Keon
Lee Young-Hoon
|
|
|
Abstract
|
|
|
|
The pancreas is a mixed exocrine and endocrine gland involved in the control of many homeostatic functions. During embryogenesis, the pancreas arises from dorsal and ventral evaginations of the foregut, which subsequently fuse into a single organ. The characterization of early genes expressed in the developing pancreas is critical to understand its specification and differentiation. Pdx1 is one of the earliest markers of pancreatic development and a key molecule in its development. Sox proteins form a large class of transcriptional regulators implicated in the control of a variety of developmental processes. One member of this family, Sox9, is expressed in the developing pancreas, but little is known about the function of Sox9 in the developing pancreas. We further investigated Sox9 function during pancreatic development in Xenopus. Using a hormone-inducible inhibitory mutant of Sox9, we found that Pdx1 expression was reduced in the ventral pancreatic buds in Sox9-depleted embryos. We suggest that Sox9 gene expression may be involved in pancreatic development in Xenopus.
|
|
|
KEYWORD
|
|
|
African clawed frog, Pancreatic development, Sox9, Pdx1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|